Dr. Bryan King introduces the autism spectrum disorder (ASD), and Dr. Matthew State overviews the hunt for genes associated with autism.
In the first lecture, Dr. Bryan King introduces the autism spectrum disorder (ASD) and defines the clinical criteria that characterizes ASD. Although there is no universal drug that is used to treat ASD, there are multiple medications used in the setting of autism. King outlines the different drugs used to treat the core behavioral features of autism as well as psychiatric disorders associated with autism (e.g. ADHD and anxiety), and discusses the challenges and problems with designing clinical trials to study drugs to treat ASD, specifically with the heterogeneity of the ASD population.
In the second lecture, Dr. Matthew State overviews the hunt for genes associated with autism and explains how studying de-novo rare mutations in the germline has advanced the understanding of the genetics of autism spectrum disorder (ASD). Studying a cohort of families with one affected individual and one unaffected sibling, they were able to map multiple genes involved in ASD. Because of the complexity of the developing brain, the same gene could act upon different regions of the brain at different times during development. Therefore, after identifying genes associated with ASD, they characterized the region and time during development where these genes are expressed and more likely to have an effect that is associated with ASD.
Dr. Bryan King is a professor of Child Psychiatry and Vice-Chair of Psychiatry at the University of California, San Francisco. He obtained his B.S. degree from University of California, Irvine (1979) and received his medical degree from the Medical College of Wisconsin (1983). He continued his medical training with an internship in internal medicine (1984), a residency in Psychiatry (1987) and a Fellowship in Child and Adolescent Psychiatry (1990) at University of California, Los Angeles. In 2014, King completed a master in business from George Washington University School of Business.
King has played a role in key clinical leadership positions at Seattle Children’s Hospital, the Dartmouth-Hitchcock Medical Center and Children’s Hospital at Dartmouth-Hitchcock, and the UCLA Neuropsychiatric Institute and Hospital. At UCSF, his laboratory focuses on the understanding of developmental disorders, in particular, ASD. Recently his research is primarily directed at pharmacological or psychosocial treatments for ASD. Learn more about King’s research at his lab website:
Autism, ADHA Articles and Videos